The 49ers and Panthers are set for a Monday Night Football showdown with playoff implications on the line tonight at Levi’s Stadium in Santa Clara. Currently, the 49ers own the last playoff spot in the NFC, but the Panthers are just one game behind them. Can Carolina pull off the upset and catch San Francisco? Let’s take a look at some game lines, odds, and more for tonight’s game. Oct 19, 2025; East Rutherford, New Jersey, USA; Carolina Panthers quarterback Bryce Young (9) throws the ball in the third quarter against the New York Jets at MetLife Stadium. Mandatory Credit: Robert Deutsch – Imagn Images Game Lines Spread: SF -7.5 Moneyline: CAR +320 | SF -410 Total Points: Over 49.5 (-110) | Under 49.5 (-110) TD Scorer Odds PlayerAnytime TDFirst TD2+ TDsChristian McCaffrey−380+275+140Rico Dowdle−145+550+400George Kittle+120+750+750Tetairoa McMillan+145+1200+1000Jauan Jennings+190+1100+1500Ricky Pearsall+215+1200+1900Brian Robinson Jr.+360+1900+3000Xavier Legette+360+2500+3500Jalen Coker+400+2500+4000Ja’Tavion Sanders+425+3000+4500Brock Purdy+450+2500+4500Chuba Hubbard+500+2800+5500SF 49ers D/ST+500+2800+5000CAR Panthers D/ST+550+3000+5500Tommy Tremble+750+4000+9000Bryce Young+750+4000+8000Kyle Juszczyk+800+4000+10000Demarcus Robinson+850+4000+9000Kendrick Bourne+900+4000+11000Jordan Watkins+1000+4500+11000Jordan James+1000+4500+11000Brycen Tremayne+1000+5500+14000Jake Tonges+1100+5000+12000Luke Farrell+1300+6000+17000Skyy Moore+1500+6500+16000Mitchell Evans+1500+9000+19000James Mitchell+1600+7500+18000Jimmy Horn Jr.+1800+8000+18000Hunter Renfrow+1800+9000+20000Isaac Guerendo+2000+7500+20000Trevor Etienne+2800+11000+25000No Touchdown Scorer+17000—— Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers running back Christian McCaffrey (23) runs the ball for a touchdown in the second half against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian – Imagn Images Remember To Always Bet On Sports Responsibly Betting on sports should always feel fun, exciting, and under control. That’s why responsible wagering matters so much. When you approach betting with the right mindset and clear limits, you put yourself in the best position to enjoy the action without letting it take over your day, your budget, or your peace of mind. Responsible betting isn’t about taking the fun out of sports. It’s about making sure the fun stays fun. A few key reminders go a long way: Set a budget before you bet and stick to it Treat your wagers as entertainment, not a source of income Never chase losses Know when to take a break Responsible betting also helps you make sharper decisions. When you’re not stressed, emotional, or overextended, you’re more likely to analyze matchups clearly, shop for the best odds, and avoid unnecessary risks. You stay focused on smart plays instead of impulsive ones. It also keeps the experience sustainable. Sports betting should fit comfortably into your life. When you stay disciplined, you’re able to enjoy the season, track your picks, and stay part of the conversation without feeling overwhelmed. At the end of the day, responsible betting protects your bankroll, your enjoyment, and your long-term love of the game. Gambling problem? Call 1-800-GAMBLER. Available in AZ, CT, CO, IA, IL, IN, KS, KY, LA, MA, MD, MI, NJ, NY, PA, OH, TN, VA, VT, WV, WY only. Full T&C apply. Responsible Gaming Resources. Visit morethanagame.nc.gov in NC. Oct 5, 2025; Charlotte, North Carolina, USA; Carolina Panthers running back Rico Dowdle (5) reacts after scoring a touchdown with Carolina Panthers tight end Tommy Tremble (82) and Carolina Panthers tight end Mitchell Evans (84) during the fourth quarter against the Miami Dolphins at Bank of America Stadium. Mandatory Credit: Cory Knowlton – Imagn Images
